[x_section bg_color=”#1e73be” style=”margin: 0px 0px 0px 0px; padding: 45px 0px 45px 0px; “][x_row inner_container=”true” marginless_columns=”false” bg_color=”” style=”margin: 0px auto 0px auto; padding: 0px 0px 0px 0px; “][x_column bg_color=”” type=”1/1″ style=”padding: 0px 0px 0px 0px; “][x_gap size=”150px”][/x_column][/x_row][/x_section][x_section style=”margin: 0px 0px 0px 0px; padding: 0px 0px 0px 0px; “][x_row inner_container=”true” marginless_columns=”false” bg_color=”” style=”margin: 0px auto 0px auto; padding: 0px 0px 0px 0px; “][x_column bg_color=”#ffffff” type=”2/3″ class=”left-text ” style=”padding: 0px 0px 0px 0px; “][x_gap size=”20px”][x_custom_headline level=”h2″ looks_like=”h3″ accent=”false”]Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS)[/x_custom_headline][x_custom_headline level=”h4″ looks_like=”h3″ accent=”false” class=”center-text “]UPDATE 30/11/18[/x_custom_headline][x_text]Dear THESEUS Team,

After a long gap in communication, we are happy to be able to update you on the excellent progress of the THESEUS Study. This long delay has been due to the wait for the NIHR to agree contracts with Cardiff University. We are updating the RSTN webpage as we speak, so this will reflect your contribution soon!
Following the collection and analysis of the THESEUS clinician survey results, we were able to inform the design of a Prospective Observational study into the management of patients with HS. This was in response to the NIHR HTA call for proposals into the management of HS.
Together with the Dr John Ingram, a UK Dermatology Consultant who is an expert on HS, colleagues at Cardiff University Clinical Trials Unit, Centre for Evidence Based Dermatology, a GP representative, and the HS Trust (representing patients), we were able to successfully secure grant funding to the tune of £660,000 for our study.
So a HUGE well done to everyone for their efforts and enthusiasm. Now the real work starts!
We are currently recruiting 10 trial sites, which will have a mixture of surgeons and dermatologists with an interest in HS. We aim to start recruiting patients to the 5 arms of the study in October 2019. We will follow them for 1 year.
In terms of outputs from the work you contributed to, we have delivered oral presentations at the following meetings:
Combined Services Plastic Surgery Society Meeting (CSPSS), 11-12th October 2018
British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS) Winter meeting, 28-30th November 2018.
Now the contracts have been signed, we can submit the paper of our results to a Plastic Surgery Journal, and if/when it is accepted, we will provide you with the citation and a copy of the manuscript – watch this space.
If you have any comments or questions, we’d love to hear from you, and we look forward to working with you in the near future.
Best wishes,
Rachel Howes and Jeremy Rodrigues
THESEUS Steering Group

[/x_text][x_line][x_custom_headline level=”h2″ looks_like=”h3″ accent=”false”]Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS)[/x_custom_headline][x_text]A recent James Lind Alliance exercise identified shared priorities for research in hidradenitis suppurativa (HS) (http://www.jla.nihr.ac.uk/priority-setting-partnerships/hidradenitis-suppurativa/top-10-priorities/).  Eight of the top ten priorities focus on treatment uncertainties, including medical and surgical management issues and the treatment of acute flares and long-term disease.

Following this, the NIHR’s Health Technology Assessment programme has called for a research study into the management of HS.

The RSTN is collaborating with the UK Dermatology Clinical Trials Network (UKDCTN) who funded the James Lind Alliance exercise to prepare a submission to the NIHR in response to the call.

Question

What are the best management options for HS when first line treatments fail?

Plan

  1. Separate national surveys of surgeons and patients to inform the NIHR application. These surveys will be critical in describing the landscape of treatment of HS across the UK, identifying variation in practice, and clarifying the feasibility of different future studies.  The study of surgeons will harness the RSTN to ensure comprehensive national coverage
  1. If successfully funded by NIHR, the main project will comprise a national non-randomised study with prospective and retrospective elements, qualitative research exploring clinician and patient decision-making, and a consensus-building exercise. It is anticipated that this will lead to a national randomised controlled trial in HS.

Register your interest

The clinician surveys have been completed. A submission to the NIHR is in development. If you have an interest in HS and would like more information, please email theseus.study@gmail.com.

 

Acknowledgements:

The Theseus Steering Group would like to acknowledge data contributed by: Alice Wignall, Anais Rosich-Medina, Rajshree Jayarajan, Sandra McAllister, Catriona Luney, Matthew Gardiner, Kshem Senarath-Yapa.[/x_text][/x_column][x_column bg_color=”” type=”1/3″ style=”padding: 0px 0px 0px 0px; “][x_gap size=”20px”][x_image type=”none” src=”https://reconstructivesurgerytrials.net/wp-content/uploads/2017/10/THESEUS.png” alt=”” link=”false” href=”#” title=”” target=”” info=”none” info_place=”top” info_trigger=”hover” info_content=””][x_accordion][x_accordion_item title=”Status” open=”true”][icon_list][icon_list_item type=”check-square-o”]Clinician survey [/icon_list_item][icon_list_item type=”check-square-o”]NIHR Funding [/icon_list_item] [icon_list_item type=”square”]Recruiting centres[/icon_list_item][icon_list_item type=”square-o”]Data collection [/icon_list_item][icon_list_item type=”square-o”]Data analysis [/icon_list_item] [icon_list_item type=”square-o”]Manuscript submission [/icon_list_item][icon_list_item type=”square-o”]Publication [/icon_list_item][/icon_list][/x_accordion_item][x_accordion_item title=”Development group” open=”false”]John Ingram
Chief Investigator
Clinical Senior Lecturer in Dermatology
Cardiff University

Tara Burton
Founder, HS Trust

Rebecca Cannings-John
Research Fellow in Statistics
Cardiff University

Kerry Hood
Professor & Director, Centre for Trials Research
Cardiff University

Rachel Howes
Plastic Surgery Registrar
Odstock Hospital, Salisbury

Jeremy Rodrigues
NIHR Postdoctoral Fellow in Plastic Surgery
University of Oxford

Kim Thomas
Professor of Applied Dermatology Research & Co-Director of the Centre of Evidence Based Dermatology
University of Nottingham

Emma Thomas-Jones
Research Fellow & Senior Trial Manager in Infections and Devices
Cardiff University

Fiona Collier
GP with Specialist Interest in Dermatology
NHS Forth Valley

Paul Tappenden
Reader in Health Economic Modelling
University of Sheffield

Paul Leighton
Research Fellow
University of Nottingham[/x_accordion_item][x_accordion_item title=”Collaborators” open=”false”]In addition to the Steering Group, the following collaborators met the criteria for inclusion as authors of the preliminary study:

Tert van Alphen
Maartin Hoogbergen
Kai Yuen Wong
Kate Richards
Ali Arnaout
Louise Glanvill
Tim Goodacre
Thomas Dobbs
Suzanne Thomson
Katerina Anesti
David Izadi
Declan Collins
Justin Wormald
Richard Boulton
Andrew Williams
Edward Westcott
Stephanie Hili
Raina Zarb Adami
Katie Young
Ben Way
Pouya Mafi
Anna Allan

Other contributors are listed in the Acknowledgements section of the webpage.[/x_accordion_item][x_accordion_item title=”Funding” open=”false”][/x_accordion_item][x_accordion_item title=”Downloads” open=”false”][/x_accordion_item][x_accordion_item title=”Contact” open=”true”]theseus.study@gmail.com[/x_accordion_item][/x_accordion][/x_column][/x_row][/x_section]