TRIGGER Trial
Trigger finger is one of the most common conditions seen by hand surgeons. Different non-operative treatments (e.g. physiotherapy, splinting and NSAIDs) have been described with little evidence to support the usage. The mainstay of non-operative treatment remains intermediate-acting steroid injection with or without a local anesthetic added. Operative management is by release of the A1 pulley, either percutaneously or with open surgery.
A recent systematic review showed moderate evidence that steroid injections are an effective initial treatment for trigger fingers. However, this evidence is based on two small studies of poor quality with a short follow-up of just four months. There is high quality evidence that trigger digits can be managed safely by open or percutaneous surgical release, but there are only 3 RCTs with several shortcomings comparing steroid injection with surgery.
We propose a large, international, multicenter, randomized controlled trial to compare steroid injection and surgery in treating trigger fingers with follow-up of one year. At the end of this study we should be able to make an evidence-based recommendation on how to treat a patient with a trigger finger.
Population: Adults with ≥ 1 trigger fingers
Intervention: Surgical release using surgeon’s preferred technique (open or percutaneous)
Control: ≥ 1 injections with steroid injection (steroid of choice, with or without local anesthetic added)
Outcome:
- Primary outcome: resolution of triggering
- Secondary outcome: level of pain, hand function (PROM), costs and complications
- Subgroup analysis: type of surgery, type of injection, thumb vs long digits, diabetes, rheumatoid arthritis
- Follow-up: 6 and 12 months
Getting involved
Thank you to all of the collaborators involved in the TRIGGER Survey. The study is finished and data is being analysed. It was presented on Friday 15th June at FESSH.
Trigger Finger Webinar
Date: Wednesday 21st February
Time: 1900-2100 GMT (London)
Location: Zoom webinar service
Thank you to those that attended. Certificates will be sent shortly.
Who should attend?
- Clinicians who treat trigger finger and would like to find out about the current evidence.
- Clinicians interested in designing a randomised controlled trial relating to the treatment of trigger finger.
Learning objectives
- Identify areas of clinical uncertainty
- Learn about the British Society for Surgery of the Hand Evidence for Surgical Treatment (BEST) Guidelines for trigger finger
- Gain insight into the research collaborative model developed in the UK
- Find out about the TRIGGER study, a pan European research study into trigger finger treatment
- Help design a randomised controlled trial for trigger finger
Programme – Starts 1900 GMT (London time)
1900 Welcome and introduction to the webinar. Mr Richard Pinder MD FRCS(Plast) DipHandSurg, Hull, UK
1910 Trigger fingers: how do you treat them? Emmi Friedman MD EPOBRAS, Jeroen Bosch Hospital, Den Bosch, The Netherlands
1920 Discussion
1930 BEST Guidelines for trigger finger. Jeremy Rodrigues MD PhD, University of Oxford, UK
1940 Discussion
2000 Power of research collaboratives. Matt Gardiner MD PhD FRCS(Plast), Oxford, UK
2020 Introducing the TRIGGER Trial. Anita Dijksterhuis MD, UMC Utrecht, The Netherlands
2030 Discussion and brainstorming RCT
2100 Close
Certificates of attendance will be emailed to those at the close of the meeting.
The Trigger Webinar Panel
Richard Pinder
Emmi Friedeman
Matt Gardiner
Jeremy Rodrigues
Anita Dijksterhuis
Tim Davis
Abhi Jain