Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS)

A recent James Lind Alliance exercise identified shared priorities for research in hidradenitis suppurativa (HS) (  Eight of the top ten priorities focus on treatment uncertainties, including medical and surgical management issues and the treatment of acute flares and long term disease.

Following this, the NIHR’s Health Technology Assessment programme has called for a research study into the management of HS (

The RSTN is collaborating with the UK Dermatology Clinical Trials Network (UKDCTN) who funded the James Lind Alliance exercise to prepare a submission to the NIHR in response to the call.


What are the best management options for HS when first line treatments fail?


  1. Separate national surveys of surgeons and patients to inform the NIHR application. These surveys will be critical in describing the landscape of treatment of HS across the UK, identifying variation in practice, and clarifying the feasibility of different future studies.  The study of surgeons will harness the RSTN to ensure comprehensive national coverage
  1. If successfully funded by NIHR, the main project will comprise a national non-randomised study with prospective and retrospective elements, qualitative research exploring clinician and patient decision-making, and a consensus-building exercise. It is anticipated that this will lead to a national randomised controlled trial in HS.

Register your interest

The clinician surveys have been completed. A submission to the NIHR is in development. If you have an interest in HS and would like more information, please email

  • Pilot centre data collection
  • National data collection
  • Data analysis
  • Manuscript submission
  • Publication
John Ingram
Chief Investigator
Clinical Senior Lecturer in Dermatology
Cardiff University

Tara Burton
Founder, HS Trust

Rebecca Cannings-John
Research Fellow in Statistics
Cardiff University

Kerry Hood
Professor & Director, Centre for Trials Research
Cardiff University

Rachel Howes
Plastic Surgery Registrar
Odstock Hospital, Salisbury

Jeremy Rodrigues
NIHR Academic Clinical Fellow in Plastic Surgery
University of Oxford

Kim Thomas
Professor of Applied Dermatology Research & Co-Director of the Centre of Evidence Based Dermatology
University of Nottingham

Emma Thomas-Jones
Research Fellow & Senior Trial Manager in Infections and Devices
Cardiff University

Dr Fiona Collier
GP with Specialist Interest in Dermatology
NHS Forth Valley