Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS)
A recent James Lind Alliance exercise identified shared priorities for research in hidradenitis suppurativa (HS) (http://www.jla.nihr.ac.uk/priority-setting-partnerships/hidradenitis-suppurativa/top-10-priorities/). Eight of the top ten priorities focus on treatment uncertainties, including medical and surgical management issues and the treatment of acute flares and long term disease.
Following this, the NIHR’s Health Technology Assessment programme has called for a research study into the management of HS (https://www.nihr.ac.uk/funding-and-support/funding-opportunities/1798-management-of-hidradenitis-suppurativa/6834).
The RSTN is collaborating with the UK Dermatology Clinical Trials Network (UKDCTN) who funded the James Lind Alliance exercise to prepare a submission to the NIHR in response to the call.
What are the best management options for HS when first line treatments fail?
- Separate national surveys of surgeons and patients to inform the NIHR application. These surveys will be critical in describing the landscape of treatment of HS across the UK, identifying variation in practice, and clarifying the feasibility of different future studies. The study of surgeons will harness the RSTN to ensure comprehensive national coverage
- If successfully funded by NIHR, the main project will comprise a national non-randomised study with prospective and retrospective elements, qualitative research exploring clinician and patient decision-making, and a consensus-building exercise. It is anticipated that this will lead to a national randomised controlled trial in HS.
Register your interest
The project will use similar methodology to the WIRE Study. Collaborators will submit a ‘denominator’ list of all eligible clinicians and be expected to get a high response rate. This will lead to Pubmed citation as a collaborator.
The surveys are currently being finalised. Email email@example.com to register interest.
Clinical Senior Lecturer in Dermatology
Founder, HS Trust
Research Fellow in Statistics
Professor & Director, Centre for Trials Research
Plastic Surgery Registrar
Odstock Hospital, Salisbury
NIHR Academic Clinical Fellow in Plastic Surgery
University of Oxford
Professor of Applied Dermatology Research & Co-Director of the Centre of Evidence Based Dermatology
University of Nottingham
Research Fellow & Senior Trial Manager in Infections and Devices
Dr Fiona Collier
GP with Specialist Interest in Dermatology
NHS Forth Valley